Title

Palmitoylation of the sodium hydrogen exchanger isoform 1 (NHE1): a novel post-translational protein modification and its regulation of NHE1

Date of Award

Spring 5-21-2018

Document Type

Undergraduate Honors Thesis

Degree Name

Bachelor of Arts in Biochemistry

Department

Chemistry & Biochemistry

Advisor

Joseph Provost

Abstract

The sodium-hydrogen exchanger isoform 1 (NHE1) is a ubiquitously expressed transmembrane transporter protein involved in regulating intracellular pH and interacts with a variety of proteins involved in cell signaling, proliferation, and cell motility. The protein has an extended cytosolic tail known as the regulatory region. This project investigates the role of palmitoylation, a reversible fatty acid modification on cysteine amino acids, in the function and behavior of NHE1.

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