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Molecular and Cellular Neuroscience

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Biology | Cell Biology | Laboratory and Basic Science Research | Molecular and Cellular Neuroscience


Expansions of polygutamine-encoding stretches in several genes cause neurodegenerative disorders including Huntington's Disease and Spinocerebellar Ataxia type 3. Expression of the human disease alleles in Drosophila melanogaster neurons recapitulates cellular features of these disorders, and has therefore been used to model the cell biology of these diseases. Here, we show that polyglutamine disease alleles expressed in Drosophila photoreceptors disrupt actin structure at rhabdomeres, as other groups have shown they do in Drosophila and mammalian dendrites. We show this actin regulatory pathway works through the small G protein Rac and the actin nucleating protein Form3. We also find that Form3 has additional functions in photoreceptors, and that loss of Form3 results in the specification of extra photoreceptors in the eye


Published in final form at:

Vu, Annie, Tyler Humphries, Sean Vogel, Adam Haberman. Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors. Molecular and Cellular Neuroscience, 93. 2018. doi: 10.1016/j.mcn.2018.08.005.