Document Type
Article
Publication Date
2023
Journal Title
Pharmaceutics
Volume Number
15
Issue Number
4
First Page
1
Last Page
14
DOI
https://doi.org/10.3390/pharmaceutics15041301
Version
Publisher PDF: the final published version of the article, with professional formatting and typesetting
Creative Commons License
This work is licensed under a CC BY License.
Disciplines
Engineering
Abstract
The ability to engineer and predict drug release behavior during treatment is critical to the design and implementation of effective drug delivery systems. In this study, a drug delivery system consisting of a methacrylate-based polymer and flurbiprofen was studied, and its release profile in a controlled phosphate-buffered saline solution was characterized. The polymer, which was 3D printed and processed in supercritical carbon dioxide under different temperature and pressure settings, showed sustained drug release over a prolonged period. A computer algorithm was used to determine the drug release time duration before reaching steady state and the maximum drug release at steady state. Several empirical models were applied to fit the release kinetic data to gain information about the drug release mechanism. The diffusion coefficients for each system were also estimated using Fick’s law. Based on the results, the influence of supercritical carbon dioxide processing conditions on the diffusion behavior is interpreted, providing insights into the effective and tunable design of drug delivery systems for targeted treatment specifications.
Digital USD Citation
Ngo, Truc T. and Kim, Jae D., "Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer" (2023). School of Engineering: Faculty Scholarship. 34.
https://digital.sandiego.edu/engineering_facpub/34