Document Type
Article
Publication Date
2023
Journal Title
iScience
Volume Number
27
Issue Number
1
DOI
https://doi.org/10.1016/j.isci.2023.108638
Version
Publisher PDF: the final published version of the article, with professional formatting and typesetting
Creative Commons License
This work is licensed under a CC BY License.
Disciplines
Engineering
Abstract
Exercise training has tremendous systemic tissue-specific health benefits, but the molecular adaptations to long-term exercise training are not completely understood. We investigated the skeletal muscle proteome of highly endurance-trained, strength-trained, and untrained individuals and performed exercise- and sex-specific analyses. Of the 6,000+ proteins identified, >650 were differentially expressed in endurance-trained individuals compared with controls. Strikingly, 92% of the shared proteins with higher expression in both the male and female endurance groups were known mitochondrial. In contrast to the findings in endurance-trained individuals, minimal differences were found in strength-trained individuals and between females and males. Lastly, a co-expression network and comparative literature analysis revealed key proteins and pathways related to the health benefits of exercise, which were primarily related to differences in mitochondrial proteins. This network is available as an interactive database resource where investigators can correlate clinical data with global gene and protein expression data for hypothesis generation.
Digital USD Citation
Emanuelsson, Eric B.; Arif, Muhammad; Reitzner, Stefan M.; Perez, Sean; Lindholm, Málene E.; Mardinoglu, Adil; Daub, Carsten; Sundberg, Carl Johan; and Chapman, Mark A., "Remodeling of the Human Skeletal Muscle Proteome Found After Long-Term Endurance Training but Not After Strength Training" (2023). School of Engineering: Faculty Scholarship. 41.
https://digital.sandiego.edu/engineering_facpub/41